Drug Combination Details
| General Information of the Combination (ID: C21358) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | 1,3-bis(2-chloroethyl)-1-nitrosourea Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Nasopharyngeal cancer
[ICD-11: 2B6B]
|
Investigative | [1] | ||
|
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | |||
|
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | |||
|
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | |||
|
Lung cancer
[ICD-11: 2C25]
|
Investigative | [1] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | HONE-1 | CVCL_8706 | Nasopharyngeal carcinoma | Homo sapiens | ||
| DBTRG-05MG | CVCL_1169 | Anaplastic astrocytoma | Homo sapiens | |||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| NCI-H460 | CVCL_0459 | Lung large cell carcinoma | Homo sapiens | |||
| A2058 | CVCL_1059 | Amelanotic melanoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| TSGH | Gastric carcinoma | Homo sapiens | ||||
| Experimental
Result(s) |
Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors. Free Radic Biol Med. 2011 Dec 15;51(12):2195-209. | |||
