Drug Combination Details

General Information of the Combination (ID: C23838)
Name Vicenin-2   NP Info  + Radiation   Drug Info 
Structure +
Disease
Lung cancer [ICD-11: 2C25]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression AKT1  Molecule Info 
Pathway MAP
                    In-vitro Model NCI-H23 CVCL_1547 Lung adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 VCN-2 can be a potential chemotherapeutic and radiosensitizing agent in NSCLC.
                    Experiment 2 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Down-regulation Expression CDKN1A  Molecule Info 
Pathway MAP
Down-regulation Expression MMP-2  Molecule Info 
Pathway MAP
Up-regulation Expression RAD50  Molecule Info 
Pathway MAP
                    In-vitro Model NCI-H23 CVCL_1547 Lung adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 VCN 2 sensitizes NCI H23 cells to radiation.
References
Reference 1 Vicenin-2 acts as a radiosensitizer of the non-small cell lung cancer by lowering Akt expression. Biofactors. 2019 Mar;45(2):200-210.
Reference 2 Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. Mol Biol Rep. 2018 Oct;45(5):1219-1225.
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