Drug Combination Details
| General Information of the Combination (ID: C24469) | |||||
|---|---|---|---|---|---|
| Name | Methylglyoxal NP Info | + | Glyoxalase I Drug Info | ||
| Structure |
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| Disease |
Colon cancer
[ICD-11: 2B90]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | STAT1 | Molecule Info |
Pathway MAP
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| In-vitro Model | SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | ||
| SW620 | CVCL_0547 | Colon adenocarcinoma | Homo sapiens | |||
| In-vivo Model | In vivo in a SW620 colon cancer xenograft model in BALB/c nude mice was use in this study. | |||||
| Experimental
Result(s) |
MG in combination with silencing of GLOI synergistically inhibited the cancer cells' proliferation, colony formation, migration, and invasion and induced apoptosis in vitro compared with the controls. | |||||
