Drug Combination Details

General Information of the Combination (ID: C24621)
Name Vinblastine   NP Info  + Nanoliposomal C6-ceramide   Drug Info 
Structure +
Disease
Colon cancer [ICD-11: 2B90]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression MAP1LC3A  Molecule Info 
Pathway MAP
                    In-vitro Model LS174T CVCL_1384 Colon adenocarcinoma Homo sapiens
Hep-G2 CVCL_0027 Hepatocellular carcinoma Homo sapiens
                    In-vivo Model Tumor cells were inoculated into the left flank of 7 week-old female athymic nude mice by subcutaneous injection of 6 * 106 LS174T cells in 0.1 mL Hanks Balanced Salt Solution.
                    Experimental
                    Result(s)		 In vitro and in vivo data support a synergistic antitumor activity of the nanoliposomal C6-ceramide and vinblastine combination, potentially mediated by an autophagy mechanism.
References
Reference 1 Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models. Cancer Lett. 2013 Sep 1;337(2):254-65.
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