Drug Details
| General Information of the Drug (ID: DR5673) | ||||
|---|---|---|---|---|
| Name |
Nanoliposomal C6-ceramide
|
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| Disease | Hepatocellular carcinoma [ICD-11: 2C12] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Vinblastine | Catharanthus roseus | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [1] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
|
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| In-vitro Model | LS174T | CVCL_1384 | Colon adenocarcinoma | Homo sapiens | ||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | Tumor cells were inoculated into the left flank of 7 week-old female athymic nude mice by subcutaneous injection of 6 * 106 LS174T cells in 0.1 mL Hanks Balanced Salt Solution. | |||||
| Experimental
Result(s) |
In vitro and in vivo data support a synergistic antitumor activity of the nanoliposomal C6-ceramide and vinblastine combination, potentially mediated by an autophagy mechanism. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | T-cell surface glycoprotein CD4 (CD4) | Molecule Info | [2] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | Click to Show/Hide | ||
| 2 | Antigen processing and presentation | |||
| 3 | Hematopoietic cell lineage | |||
| 4 | T cell receptor signaling pathway | |||
| 5 | Primary immunodeficiency | |||
| NetPath Pathway | Leptin Signaling Pathway | Click to Show/Hide | ||
| Pathway Interaction Database | TCR signaling in naï | Click to Show/Hide | ||
| 2 | ||||
| 3 | IL12-mediated signaling events | |||
| 4 | CXCR4-mediated signaling events | |||
| 5 | C-MYB transcription factor network | |||
| 6 | IL23-mediated signaling events | |||
| 7 | Arf1 pathway | |||
| 8 | Notch-mediated HES/HEY network | |||
| 9 | IL12 signaling mediated by STAT4 | |||
| Reactome | Binding and entry of HIV virion | Click to Show/Hide | ||
| 2 | Phosphorylation of CD3 and TCR zeta chains | |||
| 3 | Translocation of ZAP-70 to Immunological synapse | |||
| 4 | Generation of second messenger molecules | |||
| 5 | PD-1 signaling | |||
| WikiPathways | TCR Signaling Pathway | Click to Show/Hide | ||
| 2 | Cytokines and Inflammatory Response | |||
| 3 | Host Interactions of HIV factors | |||
| 4 | Defensins | |||
| 5 | HIV Life Cycle | |||
| 6 | TCR signaling | |||
| 7 | Costimulation by the CD28 family | |||
