Drug Combination Details
| General Information of the Combination (ID: C31690) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | Letrozole Drug Info | ||
| Structure |
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+ |
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| Disease |
Uterine cancer
[ICD-11: 2C76]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| In-vivo Model | RL-952 cells at logarithmic growth phase were suspended to a density of 5*107/mL and subcutaneously injected into ovariectomized nude mice through the dorsal skin of each side (0.1 mL/mouse, containing 5*106 cells). | |||||
| Experimental
Result(s) |
Treatment with either letrozole or curcumin could inhibit the xenografted endometrial tumor growth via inducing apoptosis in tumor cells. Combination of letrozole and curcumin further strengthened the inhibitory effect on tumor growth. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Aromatase inhibitor letrozole in synergy with curcumin in the inhibition of xenografted endometrial carcinoma growth. Int J Gynecol Cancer. 2009 Oct;19(7):1248-52. | |||
