Drug Combination Details
| General Information of the Combination (ID: C33437) | |||||
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| Name | Selenium + Paclitaxel | + | Doxorubicin | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Selenium NP Info | Drug Info | |||
| Structure |
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| Name | Paclitaxel NP Info | ||||
| Structure |
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| Disease |
Colon cancer
[ICD-11: 2B90]
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Investigative | [1] | ||
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Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | |||
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Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | |||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | |||
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Prostate cancer
[ICD-11: 2C82]
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Investigative | [1] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | T84 | CVCL_0555 | Colon adenocarcinoma | Homo sapiens | ||
| Caco-2 | CVCL_0025 | Colon adenocarcinoma | Homo sapiens | |||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| Rh2 | CVCL_A460 | Embryonal rhabdomyosarcoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | |||
| BCaP-37 | CVCL_0164 | Breast cancer | Homo sapiens | |||
| LNCaP | CVCL_0395 | Prostate carcinoma | Homo sapiens | |||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| MCF-10 | Breast cancer | Homo sapiens | ||||
| Experimental
Result(s) |
Supplementation of Selenium enhanced chemotherapeutic effect of Taxol and Doxorubicin in these cells beyond that seen with the chemotherapeutic drugs used alone. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res. May-Jun 2000;20(3A):1391-414. | |||
