Drug Combination Details

General Information of the Combination (ID: C34139)
Name D-cycloserine   NP Info  + Pioglitazone   Drug Info 
Structure +
Disease
Pain [ICD-11: MG30-MG3Z]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model Orofacial neuropathic pain mouse model was used in this study.
                    Experimental
                    Result(s)		 The DCS/PIO combination not only attenuated orofacial neuropathic pain and anxiety-related behaviors associated with trigeminal nerve injury, but it also improved mitochondrial bioenergetics.
References
Reference 1 Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury. Clin J Pain. 2018 Feb;34(2):168-177.
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