Drug Combination Details
| General Information of the Combination (ID: C36464) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | ABT-888 Drug Info | ||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | H2AFX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | RAD51 | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| U2OS | CVCL_0042 | Osteosarcoma | Homo sapiens | |||
| In-vivo Model | 2*106 human MDA-MB-231 cells were prepared with 200 uL of PBS/matrigel gel (1:1 ratio) and injected subcutaneously into the flanks of athymic nude mice (two-site injections). | |||||
| Experimental
Result(s) |
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. J Nutr Biochem. 2015 Dec;26(12):1442-7. | |||
