Drug Combination Details
| General Information of the Combination (ID: C36543) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | Dasatinib Drug Info | ||
| Structure |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ATF-4 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ATF2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BBC3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JUN | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | SUP-B15 | CVCL_0103 | B acute lymphoblastic leukemia | Homo sapiens | ||
| TOM-1 | CVCL_1895 | B acute lymphoblastic leukemia | Homo sapiens | |||
| Experimental
Result(s) |
Combining ATO and Dasatinib leads to severe cell apoptosis by activating the UPR apoptotic IRE1/JNK/PUMA axis, while neutralizing the UPR ATF4-dependent anti-apoptotic axis, activated by ATO alone. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626. | |||
