Drug Combination Details
| General Information of the Combination (ID: C42594) | |||||
|---|---|---|---|---|---|
| Name | Borneol NP Info | + | Temozolomide Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | ATM | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP7 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | FRP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| In-vivo Model | U251 cell suspension (1*109 cells) was inoculated in the armpit of 6-week-old Balb/c nude mice. | |||||
| Experimental
Result(s) |
Natural borneol enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage. | |||||
