Natural Product (NP) Details
| General Information of the NP (ID: NP2740) | |||||
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| Name |
Borneol
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| Synonyms |
isoborneol; (+)-borneol
Click to Show/Hide
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| Species Origin | Chrysanthemum x morifolium ... | Click to Show/Hide | |||
| Chrysanthemum x morifolium | |||||
| Valeriana jatamansi | |||||
| Liquidambar formosana | |||||
| Alpinia zerumbet | |||||
| Baeckea frutescens | |||||
| Annona squamosa | |||||
| Abutilon indicum | |||||
| Prunus triloba | |||||
| Disease | Asthma [ICD-11: CA23] | Investigative | [1] | ||
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C10H18O
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| PubChem CID | |||||
| Canonical SMILES |
CC1(C2CCC1(C(C2)O)C)C
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| InChI |
1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3
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| InChIKey |
DTGKSKDOIYIVQL-UHFFFAOYSA-N
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| CAS Number |
CAS 507-70-0
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| Herb ID | |||||
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| SymMap ID | |||||
| TTD Drug ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Temozolomide | Brain cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | ATM | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP7 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | FRP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| In-vivo Model | U251 cell suspension (1*109 cells) was inoculated in the armpit of 6-week-old Balb/c nude mice. | |||||
| Experimental
Result(s) |
Natural borneol enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage. | |||||
| Doxorubicin | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | POLD1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | Cell cycle arrest in G2/M phase | ||||
| Up-regulation | ROS generation | |||||
| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | |||
| In-vivo Model | U251 cells (5*107) in 100 uL PBS were injected subcutaneously into the right oxter of male nude mice. | |||||
| Experimental
Result(s) |
Borneol could enhance anticancer efficiency of doxorubicin against human glioma through triggering ROS-mediated signal. | |||||
| Target and Pathway | ||||
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| Target(s) | Transient receptor cation channel V3 (TRPV3) | Molecule Info | [4] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | Click to Show/Hide | ||
| Reactome | TRP channels | Click to Show/Hide | ||
