Drug Combination Details
| General Information of the Combination (ID: C44236) | |||||
|---|---|---|---|---|---|
| Name | Vitamin D NP Info | + | S-farnesylthiosalicylic acid Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | TIMP1 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | Primary hepatic stellate cells derived from rat's liver | Healthy | Rattus norvegicus | |||
| In-vivo Model | Male Wistar rats (300-400 g) were used in this study. | |||||
| Experimental
Result(s) |
The combined treatment may have a potential therapeutic value in the initiation of fibrotic process. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. Dig Dis Sci. 2014 Oct;59(10):2462-9. | |||
