Drug Combination Details

General Information of the Combination (ID: C48253)
Name Paclitaxel   NP Info  + Birinapant   Drug Info 
Structure +
Disease
Pancreatic cancer [ICD-11: 2C10]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Induction Cell cycle arrest in G2/M phase
                    In-vitro Model PANC-1 CVCL_0480 Pancreatic ductal adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Paclitaxel combined to birinapant could interrupt cell cycle progression by inducing G2/M arrest, whereas the single-drug treatments would not.
References
Reference 1 Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-Scale, Ion-Current-Based Quantitative Proteomics (IonStar). Mol Cell Proteomics. 2018 Apr;17(4):655-671.
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