Drug Combination Details
| General Information of the Combination (ID: C49968) | |||||
|---|---|---|---|---|---|
| Name | Ginsenoside Rg3 NP Info | + | Endostar Drug Info | ||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | mTOR | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFB | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFC | Molecule Info |
Pathway MAP
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| In-vivo Model | MCF-7 cells were inoculated under right mammary gland of female C57 mice. | |||||
| Experimental
Result(s) |
Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice. Asian Pac J Trop Med. 2016 Feb;9(2):180-3. | |||
