Drug Combination Details
| General Information of the Combination (ID: C54265) | |||||
|---|---|---|---|---|---|
| Name | Artesunate NP Info | + | Sorafenib Drug Info | ||
| Structure |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | c-RAF | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | mTOR | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-HEP-1 | CVCL_0525 | Hepatocellular carcinoma | Homo sapiens | ||
| SMMC-7721 | CVCL_0534 | Hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | For a xenograft model, 1 * 107 SK-hep1 cells were injected subcutaneously into 4-6 weeks old BALB/c nu/nu mice. | |||||
| Experimental
Result(s) |
Sor and Art combination promotes a dual inhibitory effect on both RAF/MAPK and PI3K/AKT/mTOR pathways which contributes to apoptosis burst. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Artesunate promotes sensitivity to sorafenib in hepatocellular carcinoma. Biochem Biophys Res Commun. 2019 Oct 29;519(1):41-45. | |||
