Drug Combination Details
| General Information of the Combination (ID: C55681) | |||||
|---|---|---|---|---|---|
| Name | Lactoferrin NP Info | + | Cephalosporin Drug Info | ||
| Structure |
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+ |
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| Disease |
Bovine mastitis
[ICD-11: GB21]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | BMEC-CH | CVCL_HG35 | Healthy | Bos taurus | ||
| In-vivo Model | The 22 dry cows from 4 dairy farms were 3 to 6 years old suffered from clinical mastitis with S.aureus. | |||||
| Experimental
Result(s) |
The efficacy of combination therapy with antibiotics and Lf caused antibacterial effect of antibiotics and inhibition of pro-inflammatory cytokine and chemokine production with Lf via the inhibition of NFkappaB activation. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of combination therapy with lactoferrin and antibiotics against staphylococcal mastitis on drying cows. J Vet Med Sci. 2006 Mar;68(3):205-11. | |||
