Drug Details

General Information of the Drug (ID: DR5078)
Name
Cephalosporin
Synonyms
CEPHALOSPORIN; CHEMBL1235646; Q27465008; (2R)-2-[(R)-{[(6R)-6-amino-6-carboxyhexanoyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid; REC
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Molecular Type
Small molecule
Disease Bacterial infection [ICD-11: 1A00-1C4Z] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C15H21N3O7S
PubChem CID
25058126
Canonical SMILES
C=C1CSC(N=C1C(=O)O)C(C(=O)O)NC(=O)CCCCC(C(=O)O)N
InChI
1S/C15H21N3O7S/c1-7-6-26-12(18-10(7)14(22)23)11(15(24)25)17-9(19)5-3-2-4-8(16)13(20)21/h8,11-12H,1-6,16H2,(H,17,19)(H,20,21)(H,22,23)(H,24,25)/t8-,11+,12-/m1/s1
InChIKey
JGKXEMYIHDYWCZ-JFUSQASVSA-N
TTD Drug ID
D07JVS
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Lactoferrin      Milk vetch dwarf China alphasatellite     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression p105  Molecule Info 
Pathway MAP
                    In-vitro Model BMEC-CH CVCL_HG35 Healthy Bos taurus
                    In-vivo Model The 22 dry cows from 4 dairy farms were 3 to 6 years old suffered from clinical mastitis with S.aureus.
                    Experimental
                    Result(s)		 The efficacy of combination therapy with antibiotics and Lf caused antibacterial effect of antibiotics and inhibition of pro-inflammatory cytokine and chemokine production with Lf via the inhibition of NFkappaB activation.
Target and Pathway
Target(s) Bacterial DD-carboxypeptidase (Bact vanYB)  Molecule Info  [3]
References
Reference 1 The Cephalosporin Antimicrobial Agents: A Comprehensive Review. J Vet Pharmacol Ther 11 (1):1-32. 1988.
Reference 2 Effect of combination therapy with lactoferrin and antibiotics against staphylococcal mastitis on drying cows. J Vet Med Sci. 2006 Mar;68(3):205-11.
Reference 3 A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31.
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