Drug Combination Details
| General Information of the Combination (ID: C56350) | |||||
|---|---|---|---|---|---|
| Name | Kaempferol NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Colon cancer
[ICD-11: 2B90]
|
Investigative | [1] | ||
|
Ovarian cancer
[ICD-11: 2C73]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | ATF6 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP4 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HSPA5 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PERK | Molecule Info |
Pathway MAP
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| In-vitro Model | A2780 | CVCL_0134 | Ovarian endometrioid adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Kaempferol Induces cell death in A2780 ovarian cancer cells and increases their sensitivity to cisplatin by activation of cytotoxic endoplasmic reticulum-mediated autophagy and inhibition of protein kinase B. | |||||
| Experiment 2 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
|
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| In-vitro Model | OVCAR-3 | CVCL_0465 | Ovarian serous adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | OVCAR-3 | CVCL_0465 | Ovarian serous adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. | |||||
| β. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | POLD1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | RB1 | Molecule Info |
Pathway MAP
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| In-vitro Model | LS174T | CVCL_1384 | Colon adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells. | |||||
