Drug Combination Details

General Information of the Combination (ID: C57399)
Name Voacamine   NP Info  + Doxorubicin   Drug Info 
Structure +
Disease
Osteosarcoma [ICD-11: 2B51]
Investigative [1]
Melanoma [ICD-11: 2C30]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Reversing Drug Resistance by This Combination
                 Reversing Drug Resistance     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Up-regulation Expression MAP1LC3A  Molecule Info 
Pathway MAP
                    In-vitro Model U2OS CVCL_0042 Osteosarcoma Homo sapiens
U-2 OS R1 CVCL_T429 Osteosarcoma Homo sapiens
                    Experimental
                    Result(s)		 The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells.
                    Experiment 2 Reporting the Effect of This Combination [3]
                    Biological
                    Regulation		 Induction Autophagic cell death
                    In-vitro Model U2OS CVCL_0042 Osteosarcoma Homo sapiens
U-2 OS R1 CVCL_T429 Osteosarcoma Homo sapiens
                    Experimental
                    Result(s)		 Voacamine is capable of enhancing the cytotoxic effect of DOX on MDR cells by favouring a lethal autophagic process.
                    Experiment 3 Reporting the Effect of This Combination [1]
                    In-vitro Model SaOS-2 CVCL_0548 Osteosarcoma Homo sapiens
30966M CVCL_WM43 Melanoma Homo sapiens
                    Experimental
                    Result(s)		 Voacamine modulates the sensitivity to doxorubicin of resistant osteosarcoma and melanoma cells and does not induce toxicity in normal fibroblasts.
References
Reference 1 Voacamine modulates the sensitivity to doxorubicin of resistant osteosarcoma and melanoma cells and does not induce toxicity in normal fibroblasts. J Nat Prod. 2014 Apr 25;77(4):855-62.
Reference 2 The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells. Autophagy. 2008 Nov;4(8):1020-33.
Reference 3 Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. Toxicol In Vitro. 2007 Mar;21(2):197-203.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
 Download Picture         KEGG Link