Drug Combination Details
| General Information of the Combination (ID: C66062) | |||||
|---|---|---|---|---|---|
| Name | Bufalin NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
|
Bladder cancer
[ICD-11: 2C94]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| MCF-10A | CVCL_0598 | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FADD | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | XIAP | Molecule Info |
Pathway MAP
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| In-vitro Model | T24 | CVCL_0554 | Bladder carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis. | |||||
| Experiment 3 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CBLB | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | JNK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | p38 beta | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TRAIL-R1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TRAIL-R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells. | |||||
