Drug Combination Details
| General Information of the Combination (ID: C67786) | |||||
|---|---|---|---|---|---|
| Name | Polysaccharide NP Info | + | Cyclophosphamide Drug Info | ||
| Structure |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CD178 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | FAS | Molecule Info |
Pathway MAP
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| In-vitro Model | H22 | CVCL_H613 | Hepatocellular carcinoma of the mouse | Mus musculus | ||
| In-vivo Model | H22 cells suspension (1 * 107 cell/mL) with sterile normal saline was subcutaneously inoculated into the right oxter of forty-eight healthy mice at a dose of 0.2 mL per mice. | |||||
| Experimental
Result(s) |
Combination treatment with LEP-2a and CTX processed a significantly synergistic anti-tumor effect in H22 tumor-bearing mice through Fas/FasL mediated caspase-dependent death pathway and mitochondria apoptosis pathway. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic antitumor effect of polysaccharide from Lachnum sp. in combination with cyclophosphamide in hepatocellular carcinoma. Carbohydr Polym. 2018 Sep 15;196:33-46. | |||
