Natural Product (NP) Details
| General Information of the NP (ID: NP1217) | |||||
|---|---|---|---|---|---|
| Name |
Polysaccharide
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| Species Origin | Ophiocordyceps sinensis ... | Click to Show/Hide | |||
| Ophiocordyceps sinensis | |||||
| Disease | Cancer-related fatigue [ICD-11: MG22] | Phase 4 | [1] | ||
| Herb ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cyclophosphamide | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | CD178 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | FAS | Molecule Info |
Pathway MAP
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| In-vitro Model | H22 | CVCL_H613 | Hepatocellular carcinoma of the mouse | Mus musculus | ||
| In-vivo Model | H22 cells suspension (1 * 107 cell/mL) with sterile normal saline was subcutaneously inoculated into the right oxter of forty-eight healthy mice at a dose of 0.2 mL per mice. | |||||
| Experimental
Result(s) |
Combination treatment with LEP-2a and CTX processed a significantly synergistic anti-tumor effect in H22 tumor-bearing mice through Fas/FasL mediated caspase-dependent death pathway and mitochondria apoptosis pathway. | |||||
