Drug Combination Details
| General Information of the Combination (ID: C67973) | |||||
|---|---|---|---|---|---|
| Name | Piperine NP Info | + | Temozolomide Drug Info | ||
| Structure |
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| Disease |
Brain cancer
[ICD-11: 2A00]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNE1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK4 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK6 | Molecule Info |
Pathway MAP
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| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| T98G | CVCL_0556 | Glioblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines. Bioengineered. 2020 Dec;11(1):791-800. | |||
