Drug Combination Details
| General Information of the Combination (ID: C68816) | |||||
|---|---|---|---|---|---|
| Name | Alpha linolenic acid NP Info | + | Gentamicin Drug Info | ||
| Structure |
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+ |
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| Disease |
Healthy individual
[ICD-11: N.A.]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NOS2 | Molecule Info |
Pathway MAP
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| In-vivo Model | Eight-week-old balb/c albino male mice were used in this study. | |||||
| Experimental
Result(s) |
The gentamicin administration causes nephrotoxicity and the use of alpha-linolenic acid can be helpful against this toxic effect. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Protective effect of alpha-linolenic acid on gentamicin-induced ototoxicity in mice. Somatosens Mot Res. 2017 Sep;34(3):145-150. | |||
