Drug Combination Details
| General Information of the Combination (ID: C69094) | |||||
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| Name | Chrysin NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
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Investigative | [1] | ||
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Cervix carcinoma
[ICD-11: 2E66 ]
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Investigative | [1] | |||
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Cervical cancer
[ICD-11: 2C77]
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Investigative | [1] | |||
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Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | |||
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Acute lymphoblastic leukemia
[ICD-11: 2B33]
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Investigative | [2] | |||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [2] | |||
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Colon cancer
[ICD-11: 2B90]
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Investigative | [2] | |||
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Melanoma
[ICD-11: 2C30]
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Investigative | [2] | |||
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Pancreatic cancer
[ICD-11: 2C10]
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Investigative | [2] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | |||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | |||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Chrysin can enhance the apoptosis induced by TRAIL, and the apoptosis is caspase-dependent and related to the activation of caspase 8. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MDM2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TRAIL-R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| SK-MEL-37 | CVCL_3878 | Amelanotic cutaneous melanoma | Homo sapiens | |||
| Capan-1 | CVCL_0237 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Chrysin overcomed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. | |||||
