Drug Combination Details
| General Information of the Combination (ID: C69492) | |||||
|---|---|---|---|---|---|
| Name | L-methionine NP Info | + | Ciprofloxacin Drug Info | ||
| Structure |
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+ |
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| Disease |
Chronic obstructive pulmonary disease
[ICD-11: CA22]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Pseudomonas aeruginosa strain PA01 | Microorganism model | Pseudomonas aeruginosa | |||
| In-vivo Model | Mice with PA pneumonia were used as animal model in this study. | |||||
| Experimental
Result(s) |
Intranasal L-Met treatment along with antibiotics can cure chronic PA lung infection in mice. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Chronic lung infection by Pseudomonas aeruginosa biofilm is cured by L-Methionine in combination with antibiotic therapy. Sci Rep. 2015 Nov 2;5:16043. | |||
