Drug Combination Details
| General Information of the Combination (ID: C70728) | |||||
|---|---|---|---|---|---|
| Name | Schisandrol B NP Info | + | Cyclosporin Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | GABPA | Molecule Info | ||
| Down-regulation | Expression | LDHA | Molecule Info |
Pathway MAP
|
||
| Biological
Regulation |
Induction | ROS accumulation | ||||
| In-vitro Model | HK2 | CVCL_0302 | Healthy | Homo sapiens | ||
| Experimental
Result(s) |
SchB has beneficial roles in preventing CsA induced oxidative stress, apoptosis and autophagy by enhancing cell survival via scavenging ROS. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | LDHA | Molecule Info |
Pathway MAP
|
|
| Biological
Regulation |
Increase | ATP generation | ||||
| Induction | ROS generation | |||||
| In-vitro Model | HK2 | CVCL_0302 | Healthy | Homo sapiens | ||
| Experimental
Result(s) |
Sch B appears to protect against CsA-induced nephrotoxicity by decreasing oxidative stress and cell death. | |||||
