Drug Combination Details
| General Information of the Combination (ID: C72944) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | Cabazitaxel Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | LNCaP C4-2 | CVCL_4782 | Prostate carcinoma | Homo sapiens | ||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| ARCaPM | Prostate cancer | Homo sapiens | ||||
| In-vivo Model | PC3-luc cells (2*106) per 100L per site were injected subcutaneously in athymic nude mice (BALB/c, 6-week-old). | |||||
| Experimental
Result(s) |
Genistein increases the expression of pro-apoptotic protein Bax, activates apoptotic signals, and enhances the response to cabazitaxel treatment in mCRPC cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells. Prostate. 2013 Nov;73(15):1681-9. | |||
