Drug Combination Details
| General Information of the Combination (ID: C72994) | |||||
|---|---|---|---|---|---|
| Name | Esculetin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDH2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CTNNB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PCNA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | WNT3A | Molecule Info |
Pathway MAP
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| In-vitro Model | Caco-2 | CVCL_0025 | Colon adenocarcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | |||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| In-vivo Model | Animal models were constructed by injecting HCT-116 cells in the right flank of nude mice. | |||||
| Experimental
Result(s) |
EST combined with 5-FU could increase the inhibitory effect of 5-FU on HCT-116 cells proliferation, migration and epithelial-mesenchymal transition. | |||||
