Drug Combination Details
| General Information of the Combination (ID: C73000) | |||||
|---|---|---|---|---|---|
| Name | Urolithin A NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CXCL2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL23 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vivo Model | Male mice of 6-8 weeks age with weights of 18-22 g were used in all experiments. | |||||
| Experimental
Result(s) |
Urolithin A attenuated cisplatin-induced kidney injury in mice through the down regulation of inflammatory cytokines/chemokine, immune cells, and oxidative/nitrative stress thus improving cisplatin-induced proximal tubular cell death. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress. Food Chem Toxicol. 2019 Jul;129:108-114. | |||
