Drug Combination Details
| General Information of the Combination (ID: C76205) | |||||
|---|---|---|---|---|---|
| Name | Elemene NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | FADD | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TRAIL-R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | BGC-823 | CVCL_3360 | Gastric cancer | Homo sapiens | ||
| SGC-7901 | CVCL_0520 | Human gastric cancer | Homo sapiens | |||
| Experimental
Result(s) |
Beta-elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Beta-elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts. Cell Biol Int. 2018 Sep;42(10):1377-1385. | |||
