Drug Combination Details
| General Information of the Combination (ID: C76936) | |||||
|---|---|---|---|---|---|
| Name | Elemene NP Info | + | Oxaliplatin Drug Info | ||
| Structure |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PAEP | Molecule Info | |||
| In-vitro Model | MHCC97-H | CVCL_4972 | Adult hepatocellular carcinoma | Homo sapiens | ||
| HCCLM3 | CVCL_6832 | Adult hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | Human HCC cell line MHCC97H were used to estabolish xenograft models in the BALB/c mice. | |||||
| Experimental
Result(s) |
Beta-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Beta-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1. Sci Rep. 2016 Feb 12;6:21010. | |||
