Drug Combination Details
| General Information of the Combination (ID: C77146) | |||||
|---|---|---|---|---|---|
| Name | Vernodalol NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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| Disease |
Diffuse B-cell lymphoma
[ICD-11: 2A81]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TRAIL-R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | SU-DHL-2 | CVCL_9550 | B-cell lymphoma | Homo sapiens | ||
| OCI-Ly8 | CVCL_8803 | Diffuse large B-cell lymphoma | Homo sapiens | |||
| SU-DHL-4 | CVCL_0539 | B-cell lymphoma | Homo sapiens | |||
| In-vivo Model | Tumours were induced by injecting 5*106 cells into the right side of each nude mouse. | |||||
| Experimental
Result(s) |
Vernodalol enhances TRAIL-induced apoptosis in diffuse large B-cell lymphoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Vernodalol enhances TRAIL-induced apoptosis in diffuse large B-cell lymphoma cells. Mol Carcinog. 2017 Oct;56(10):2190-2199. | |||
