Drug Combination Details
| General Information of the Combination (ID: C78022) | |||||
|---|---|---|---|---|---|
| Name | L-carnitine NP Info | + | Doxorubicin Drug Info | ||
| Structure |
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+ |
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| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Male Sprague-Dawley rats, weighing between 250 and 350 g were used in this study. | |||||
| Experimental
Result(s) |
L-carnitine can protect renal impairment functionally, biochemically and histopathologically with a corresponding reduction of oxidative stress. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | L-carnitine ameliorates doxorubicin-induced nephrotic syndrome in rats. Nephrology (Carlton). 2006 Aug;11(4):313-20. | |||
