Drug Combination Details
| General Information of the Combination (ID: C79568) | |||||
|---|---|---|---|---|---|
| Name | Tretinoin NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
|
||
| Disease |
Lung cancer
[ICD-11: 2C25]
|
Investigative | [1] | ||
|
Healthy individual
[ICD-11: N.A.]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | LT73 | CVCL_VU37 | Lung adenocarcinoma | Homo sapiens | ||
| In-vivo Model | Patient-Derived Xenograft Tumor Models were used in this study. | |||||
| Experimental
Result(s) |
Combination treatment with All-Trans Retinoic Acid prevents cisplatin-induced enrichment of CD133+ tumor-initiating cells and reveals heterogeneity of cancer stem cell compartment in lung cancer. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
|
| Experimental
Result(s) |
Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. | |||||
