Drug Combination Details
| General Information of the Combination (ID: C83756) | |||||
|---|---|---|---|---|---|
| Name | Resveratrol NP Info | + | Temozolomide Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | GFAP | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | mTOR | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | PRKAA1 | Molecule Info |
Pathway MAP
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| In-vitro Model | SHG-44 | CVCL_6728 | Astrocytoma | Homo sapiens | ||
| In-vivo Model | SHG44 cells (5*105 cells per mouse) in 5 uL of Hanks' solution were injected intracranially into the right caudate nucleus of 6- to 8-week-old female nude mice. | |||||
| Experimental
Result(s) |
Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | ATM | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | FRP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MGMT | Molecule Info | |||
| Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | XRCC6 | Molecule Info |
Pathway MAP
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| In-vitro Model | GICs | Glioblastoma Multiforme | Homo sapiens | |||
| In-vivo Model | GICs (2*105) were subcutaneously injected into the left hind flank of the 6-week-old female NOD/SCID mice. | |||||
| Experimental
Result(s) |
Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation. | |||||
