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Drug Combination Details

General Information of the Combination (ID: C97947)
Name Tetrodotoxin   NP Info  + Lidocaine   Drug Info 
Structure +
Disease
Arrhythmias [ICD-11: BC65]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Chinese hamster ovary cell line Healthy Cricetulus griseus
                    In-vivo Model The animal models were established in Sprague Dawley rats by continuous infusion of aconitine into the caudal vein or vena jugularis externa.
                    Experimental
                    Result(s)
The anti-arrhythmic effect of the combination of TTX and LID was greater than that of either TTX or LID alone.
References
Reference 1 Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias. Mar Drugs. 2019 Dec 5;17(12):685.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China