Drug Details

General Information of the Drug (ID: DR3619)
Name
Venlafaxine
Synonyms
venlafaxine; 93413-69-5; Elafax; D,L-Venlafaxine; Venlafaxina; Venlafaxinum; Effexor; 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol; 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; Efectin; CHEBI:9943; Venlafaxine [INN:BAN]; NCGC00095109-01; Venlafaxinum [INN-Latin]; Venlafaxin; Venlafaxina [INN-Spanish]; Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-; DSSTox_CID_3737; DSSTox_RID_77175; DSSTox_GSID_23737; Venlafexine; Efectin (TN); Venlafaxine (INN); CAS-93413-69-5; SR-01000762930; DL-Venlafaxine; Venflaxine EP; HSDB 6699; Venlafaxine-d6 HCl; Spectrum_001671; SpecPlus_000842; Spectrum2_000542; Spectrum3_000989; Spectrum4_001115; Spectrum5_001516; Venlafaxine EP Impurity H; CHEMBL637; EC 618-944-2; N,N,O-Didesmethylvenlafaxine; SCHEMBL35154; BSPBio_002657; KBioGR_001590; KBioSS_002151; MLS006011859; DivK1c_006938; SPECTRUM1504171; SPBio_000583; GTPL7321; DTXSID6023737; BDBM82071; KBio1_001882; KBio2_002151; KBio2_004719; KBio2_007287; KBio3_001877; HMS1922F05; HMS2090F04; HMS2093A12; HMS3714K11; HMS3886K14; Pharmakon1600-01504171; 1-{2-(dimethylamino)-1-[4-(methyloxy)phenyl]ethyl}cyclohexanol; AMY39116; HY-B0196; Tox21_111425; CCG-39577; MFCD00864385; N,N-dimethyl-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethylamine; NSC_62923; NSC758676; s5655; STK621394; AKOS005555049; Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, (+-)-; Tox21_111425_1; AC-1547; AT-6375; DB00285; MCULE-6632261838; NSC 758676; NSC-758676; SDCCGSBI-0052740.P003; NCGC00095109-02; NCGC00095109-03; NCGC00095109-04; NCGC00095109-05; NCGC00095109-06; NCGC00095109-08; NCGC00095109-20; K700; SMR002204138; WY-45655; SBI-0052740.P002; CAS_93413-69-5; CAS_99300-78-4; DB-057399; FT-0642242; FT-0675793; FT-0675795; C07187; D08670; AB00053751-08; AB00053751-10; AB00053751-11; AB00053751_12; AB00053751_13; 413V695; Q898407; SR-01000762930-3; SR-01000762930-4; BRD-A51714012-001-02-3; BRD-A51714012-003-01-1; 1-[2-dimethylamino-1-(4-methoxylphenyl)ethyl]cyclohexanol; (RS)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol; 540726-98-5
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Molecular Type
Small molecule
Disease Depression [ICD-11: 6A70-6A71] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C17H27NO2
PubChem CID
5656
Canonical SMILES
CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O
InChI
1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
InChIKey
PNVNVHUZROJLTJ-UHFFFAOYSA-N
CAS Number
CAS 93413-69-5
ChEBI ID
CHEBI:9943
TTD Drug ID
D0P1UX
DrugBank ID
DB00285
Target and Pathway
Target(s) Norepinephrine transporter (NET)  Molecule Info  [2]
Serotonin transporter (SERT)  Molecule Info  [2]
KEGG Pathway Serotonergic synapse Click to Show/Hide
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
Panther Pathway 5HT1 type receptor mediated signaling pathway Click to Show/Hide
2 5HT2 type receptor mediated signaling pathway
3 5HT3 type receptor mediated signaling pathway
4 5HT4 type receptor mediated signaling pathway
5 Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters Click to Show/Hide
WikiPathways Monoamine Transport Click to Show/Hide
2 SIDS Susceptibility Pathways
3 NRF2 pathway
4 Synaptic Vesicle Pathway
5 Serotonin Transporter Activity
6 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7321).
Reference 2 Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.