Molecule Details
| General Information of the Molecule | ||||
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| Name |
Serotonin transporter (SERT)
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| Synonyms |
Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
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| Gene Name |
SLC6A4
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| Gene ID | ||||
| Sequence |
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT PGTFKERIIKSITPETPTEIPCGDIRLNAV Click to Show/Hide
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| Function |
Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization.
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| Uniprot ID | ||||
| TC Number | ||||
| Pfam | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | Paroxetine | NP Info | Approved | Areca catechu |
| Drug(s) of This Target | ||||
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| 1 | Bupropion | Drug Info | Approved | Nicotine use disorder |
| 2 | Diethylpropion | Drug Info | Approved | Obesity |
| 3 | Duloxetine | Drug Info | Approved | Depression |
| 4 | Fluoxetine | Drug Info | Approved | Depression |
| 5 | Fluvoxamine | Drug Info | Approved | Depression |
| 6 | Paracetamol | Drug Info | Approved | Pain |
| 7 | Venlafaxine | Drug Info | Approved | Depression |