Drug Details

General Information of the Drug (ID: DR6027)
Name
Bupropion
Synonyms
bupropion; Amfebutamone; 34911-55-2; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; Amfebutamon; Wellbutrin; amfebutamonum; Amfebutamona; (+-)-Bupropion; 34841-39-9; Elontril; Wellbatrin; Zyban; AMFEBUTAMONE HCl; Bupropion SR; Bupropion hydrocloride; CHEMBL894; alpha-(tert-butylamino)-m-chloropropiophenone; CHEBI:3219; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; Bupropion [INN:BAN]; Amfebutamonum [INN-Latin]; Amfebutamona [INN-Spanish]; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; UNII-01ZG3TPX31; Bupropion (INN); Bupropion (USAN); BW-323; NSC315851; bupropion (amfebutamone); BRN 2101062; 01ZG3TPX31; Bupropion-[d9]; Zyban (Salt/Mix); 150988-80-0; Budeprion (Salt/Mix); Spectrum_001663; Wellbutrin (Salt/Mix); SpecPlus_000954; (.+/-.)-Bupropion; 2-(Tert-Butylamino)-3'-chloropropiophenone; Prestwick0_000249; Prestwick1_000249; Prestwick2_000249; Prestwick3_000249; Spectrum2_001659; Spectrum3_000644; Spectrum4_000614; Spectrum5_001406; (+-)-2-(tert-Butylamino)-3'-chlorpropiophenon; Lopac0_000166; SCHEMBL38777; BSPBio_000038; BSPBio_002247; KBioGR_001168; KBioSS_002143; (+-)-2-(tert-Butylamino)-3'-chloropropiophenone; MLS001424015; DivK1c_007050; SPBio_001817; SPBio_002257; BPBio1_000042; GTPL7135; DTXSID7022706; HSDB 6988; KBio1_001994; KBio2_002143; KBio2_004711; KBio2_007279; KBio3_001467; HMS2051G10; HMS2089G14; HMS2232P04; HMS3369P11; HMS3393G10; 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-; AMY32517; BCP24193; 8068AH; AC-197; BBL029065; BDBM50048392; STL373006; 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (+-)-; AKOS015961770; CCG-100858; CCG-204261; DB01156; NC00108; NSC 758686; SDCCGSBI-0050154.P004; MRF-0000143; NCGC00015122-03; NCGC00015122-04; NCGC00015122-06; NCGC00015122-07; NCGC00015122-09; NCGC00015122-14; NCGC00015122-20; NCGC00089751-02; AM807634; NCI60_002714; SMR000472526; SBI-0050154.P003; DB-048697; AB00053756; .alpha.-(tert-Butylamino)-m-chloropropiophenone; 3'-Chloro-alpha-(tert-butylamino)propiophenone; C-6222; C06860; D07591; Propiophenone, 2-(tert-butylamino)-3'-chloro-; AB00053756-16; AB00053756-18; AB00053756-19; AB00053756_20; AB00053756_21; 2-tert-Butylamino-1-(3-chlorophenyl)propan-1-one; L000725; Q834280; (.+/-.)-2-(tert-Butylamino)-3'-chloropropiophenone; BRD-A05186015-003-05-7; BRD-A05186015-003-09-9; 2-(tert-Butylamino)-1-(3-chlorophenyl)-1-propanone #; 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 1-Propanone, 1-(3-chlorophenyl)-2-[(1, 1-dimethylethyl)amino]-; 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (.+/-.)-
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Molecular Type
Small molecule
Disease Nicotine use disorder [ICD-11: 6C4A] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C13H18ClNO
PubChem CID
444
Canonical SMILES
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
InChI
1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
InChIKey
SNPPWIUOZRMYNY-UHFFFAOYSA-N
CAS Number
CAS 34911-55-2
ChEBI ID
CHEBI:3219
TTD Drug ID
D0X4ZR
DrugBank ID
DB01156
Target and Pathway
Target(s) Norepinephrine transporter (NET)  Molecule Info  [2]
Serotonin transporter (SERT)  Molecule Info  [2]
KEGG Pathway Serotonergic synapse Click to Show/Hide
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
Panther Pathway 5HT1 type receptor mediated signaling pathway Click to Show/Hide
2 5HT2 type receptor mediated signaling pathway
3 5HT3 type receptor mediated signaling pathway
4 5HT4 type receptor mediated signaling pathway
5 Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters Click to Show/Hide
WikiPathways Monoamine Transport Click to Show/Hide
2 SIDS Susceptibility Pathways
3 NRF2 pathway
4 Synaptic Vesicle Pathway
5 Serotonin Transporter Activity
6 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Reference 2 Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.