Drug Details
| General Information of the Drug (ID: DR5605) | ||||
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| Name |
Polyinosinic acid-polycytidylic acid
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| Synonyms |
Polyinosinic acid-polycytidylic acid; Poly(rI).poly(rC); 24939-03-5; Poly C poly I; Poly I:poly C; Poly(I).poly(C); Poly(rI).(rC); PI:C; Poly(I).poly(C) complex; Polyinosinate:polycytidylate; Poly IC; Polycytidylic-polyinosinic acid; Polyinosinic-polycytidylic acid; Polyinosinate-polycytidylate complex; Polyinosinic acid:polycytidylic acid; Polyinosinic-polycytidylic acid complex; Polyriboinosinic-polyribocytidylic acid; NSC-120949; Polyriboinosinic: polyribocytidylic acid; Poly(cytidylic acid)-poly(inosinic acid); Polyinosinic:polycytidylic acid; Polyinosinic acid:polycytidylic acid complex; Polyriboinosinic-polyribocytidylic acid complex; Polyribocytidylic acid-polyriboinosinic acid complex; Polyriboinosinic acid-polyribocytidylic acid complex; Poly(I:C) (VAN); NSC 123233; UNII-3R630IWW5I; UNII-O84C90HH2L; Poly(I).poly(C); Poly(I).poly(C) complex; Polyinosinic:polycytidylic acid copolymer; 3R630IWW5I; O84C90HH2L; DTXSID90947819; AKOS025402393; AC-8822; Q7226506; 5'-aInosinic acid, homopolymer, complex with 5'-acytidylic acid homopolymer (1:1); 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1) (9CI); 5'-Inosinic acid, polymers, complex with 5'-cytidylic acid polymers (1:1) (8CI); [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
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| Molecular Type |
Small molecule
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| Disease | Middle east respiratory syndrome [ICD-11: 1D64] | Investigative | [1] | |
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
C19H27N7O16P2
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| PubChem CID | ||||
| Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O
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| InChI |
1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
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| InChIKey |
ACEVNMQDUCOKHT-ZLOOHWKQSA-N
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| TTD Drug ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Arsenic trioxide | Realgar and orpiment | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BID | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TLR3 | Molecule Info |
Pathway MAP
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| In-vitro Model | SMMC-7721 | CVCL_0534 | Hepatocellular carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. | |||||
| Target and Pathway | ||||
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| Target(s) | Toll-like receptor 3 (TLR3) | Molecule Info | [1] | |
| KEGG Pathway | Toll-like receptor signaling pathway | Click to Show/Hide | ||
| 2 | Hepatitis C | |||
| 3 | Hepatitis B | |||
| 4 | Influenza A | |||
| 5 | Herpes simplex infection | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Toll receptor signaling pathway | Click to Show/Hide | ||
| Pathway Interaction Database | Endogenous TLR signaling | Click to Show/Hide | ||
| Reactome | Ligand-dependent caspase activation | Click to Show/Hide | ||
| 2 | MyD88-independent TLR3/TLR4 cascade | |||
| 3 | Trafficking and processing of endosomal TLR | |||
| 4 | RIP-mediated NFkB activation via ZBP1 | |||
| 5 | TRIF-mediated programmed cell death | |||
| 6 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||
| 7 | IKK complex recruitment mediated by RIP1 | |||
| 8 | TRAF6 mediated induction of TAK1 complex | |||
| WikiPathways | Toll-like receptor signaling pathway | Click to Show/Hide | ||
| 2 | Cytosolic sensors of pathogen-associated DNA | |||
| 3 | Toll-Like Receptors Cascades | |||
| 4 | MyD88-independent cascade | |||
| 5 | Trafficking and processing of endosomal TLR | |||
| 6 | Regulation of toll-like receptor signaling pathway | |||
