Drug Details

General Information of the Drug (ID: DR5773)
Name
Fernblock
Disease Photoaging [ICD-11: EJ20] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Sulforaphane      Brassica oleracea     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression IL1B  Molecule Info 
Pathway MAP
Down-regulation Expression MMP-1  Molecule Info 
Pathway MAP
Down-regulation Expression MMP-3  Molecule Info 
Pathway MAP
                    In-vitro Model WM115 CVCL_0040 Melanoma Homo sapiens
WM266-4 CVCL_2765 Melanoma Homo sapiens
                    Experimental
                    Result(s)		 The combination of sulforaphane and fernblock XP improves individual beneficial effects in normal and neoplastic human skin cell lines.
Target and Pathway
Target(s) Succinate dehydrogenase (SDHD)  Molecule Info  [3]
References
Reference 1 Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation. Int J Mol Sci. 2018 Aug 1;19(8):2250.
Reference 2 The Combination of Sulforaphane and Fernblock ? XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines. Nutrients. 2020 May 30;12(6):1608.
Reference 3 Antihypoxic and antinecrotic effect of mexidol in skin ischemia. Bull Exp Biol Med. 2005 Feb;139(2):202-6.
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