Molecule Details

General Information of the Molecule

Name

Matrix metalloproteinase-1 (MMP-1)

Synonyms

Interstitial collagenase; Fibroblast collagenase; CLG

Gene Name

MMP1

Gene ID

4312

Sequence

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

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Function

Cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Cleaves collagens of types I, II, and III at one site in the helical domain.

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Uniprot ID

MMP1_HUMAN

EC Number

EC: 3.4.24.7

Pfam

PF00045 ; PF00413 ; PF01471

KEGG ID

hsa4312

TTD ID

T52450

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

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Down-regulation

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Drug Combination 1 Down-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

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Name

Sulforaphane NP Info

Fernblock Drug Info

Structure

References

Reference 1

The Combination of Sulforaphane and Fernblock ? XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines. Nutrients. 2020 May 30;12(6):1608.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)