Drug Details
| General Information of the Drug (ID: DR5858) | ||||
|---|---|---|---|---|
| Name |
Bcl-2 siRNA
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| Molecular Type |
Small interfering RNA
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| Disease | Pancreatic cancer [ICD-11: 2C10] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Paclitaxel | Taxus brevifolia | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| In-vitro Model | U-138MG | CVCL_0020 | Astrocytoma | Homo sapiens | ||
| U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | |||
| Experimental
Result(s) |
A low dose of taxol in combination with a plasmid vector expressing Bcl-2 siRNA effectively induces apoptosis in glioblastoma cells, markedly decreases tumour cell invasion, completely inhibits in vivo angiogenesis, and remarkably suppresses both intracranial and subcutaneous tumour growth in nude mice. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Fibroblast growth factor receptor 1 (FGFR1) | Molecule Info | [3] | |
| KEGG Pathway | MAPK signaling pathway | Click to Show/Hide | ||
| 2 | Ras signaling pathway | |||
| 3 | Rap1 signaling pathway | |||
| 4 | PI3K-Akt signaling pathway | |||
| 5 | Adherens junction | |||
| 6 | Signaling pathways regulating pluripotency of stem cells | |||
| 7 | Regulation of actin cytoskeleton | |||
| 8 | Pathways in cancer | |||
| 9 | Proteoglycans in cancer | |||
| 10 | Prostate cancer | |||
| 11 | Melanoma | |||
| 12 | Central carbon metabolism in cancer | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Angiogenesis | Click to Show/Hide | ||
| 2 | FGF signaling pathway | |||
| Pathway Interaction Database | Glypican 1 network | Click to Show/Hide | ||
| 2 | Syndecan-4-mediated signaling events | |||
| 3 | N-cadherin signaling events | |||
| 4 | FGF signaling pathway | |||
| WikiPathways | Regulation of Actin Cytoskeleton | Click to Show/Hide | ||
| 2 | Endochondral Ossification | |||
| 3 | MAPK Signaling Pathway | |||
| 4 | Mesodermal Commitment Pathway | |||
| 5 | Hair Follicle Development: Induction (Part 1 of 3) | |||
| 6 | Integrated Pancreatic Cancer Pathway | |||
| 7 | Signaling Pathways in Glioblastoma | |||
| 8 | Neural Crest Differentiation | |||
| 9 | Signaling by FGFR | |||
