Drug Combination Details

General Information of the Combination (ID: C56091)
Name Paclitaxel   NP Info  + Bcl-2 siRNA   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression BCL-2  Molecule Info 
Pathway MAP
                    In-vitro Model U-138MG CVCL_0020 Astrocytoma Homo sapiens
U-251MG CVCL_0021 Astrocytoma Homo sapiens
                    Experimental
                    Result(s)		 A low dose of taxol in combination with a plasmid vector expressing Bcl-2 siRNA effectively induces apoptosis in glioblastoma cells, markedly decreases tumour cell invasion, completely inhibits in vivo angiogenesis, and remarkably suppresses both intracranial and subcutaneous tumour growth in nude mice.
References
Reference 1 Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth. J Cell Mol Med. 2009 Oct;13(10):4205-18.
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