Drug Details
| General Information of the Drug (ID: DR6642) | ||||
|---|---|---|---|---|
| Name |
Thymic stromal lymphopoietin
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| Disease | Colon cancer [ICD-11: 2B90] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug | ||||||
| Acteoside | Cistanche | Click to Show/Hide the Molecular Data of This NP | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL1B | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MDM2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vitro Model | HMC-1 | CVCL_0003 | Mast cell leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | TNF-related apoptosis-inducing ligand (TRAIL) | Molecule Info | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | Click to Show/Hide | ||
| 2 | FoxO signaling pathway | |||
| 3 | Apoptosis | |||
| 4 | Natural killer cell mediated cytotoxicity | |||
| 5 | Measles | |||
| 6 | Influenza A | |||
| NetPath Pathway | IL2 Signaling Pathway | Click to Show/Hide | ||
| 2 | IL4 Signaling Pathway | |||
| 3 | TGF_beta_Receptor Signaling Pathway | |||
| 4 | TNFalpha Signaling Pathway | |||
| 5 | Leptin Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | Click to Show/Hide | ||
| Pathway Interaction Database | TRAIL signaling pathway | Click to Show/Hide | ||
| 2 | Caspase Cascade in Apoptosis | |||
| Reactome | Ligand-dependent caspase activation | Click to Show/Hide | ||
| 2 | Regulation by c-FLIP | |||
| 3 | RIPK1-mediated regulated necrosis | |||
| 4 | CASP8 activity is inhibited | |||
| 5 | Dimerization of procaspase-8 | |||
| 6 | TRAIL signaling | |||
| WikiPathways | Apoptosis | Click to Show/Hide | ||
| 2 | Extrinsic Pathway for Apoptosis | |||
| 3 | Apoptosis Modulation and Signaling | |||
| 4 | TP53 Network | |||
