Drug Details

General Information of the Drug (ID: DR8195)
Name
Selenite
Synonyms
selenite; Selenite ion; 14124-67-5; UNII-KXO0259XJ1; selenite(2-); KXO0259XJ1; Selenit; trioxoselenate(IV); trioxoselenate(2-); trioxidoselenate(2-); Selenium (IV) trioxide; Monohydrated selenuim dioxide; DTXSID9074517; SeO3(2-); CHEBI:18212; [SeO3](2-); C05684; Q27102911
    Click to Show/Hide
Molecular Type
Small molecule
Disease Arsenical melanosis [ICD-11: ED6Y] Phase 3 [1]
Structure
Click to Download Mol
2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
O3Se-2
PubChem CID
1090
Canonical SMILES
[O-][Se](=O)[O-]
InChI
1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2
InChIKey
MCAHWIHFGHIESP-UHFFFAOYSA-L
CAS Number
CAS 14124-67-5
ChEBI ID
CHEBI:18212
DrugBank ID
DB11127
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Genistein      Glycine max     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression AKT1  Molecule Info 
Pathway MAP
Up-regulation Expression BAX  Molecule Info 
Pathway MAP
Up-regulation Expression CDKN1A  Molecule Info 
Pathway MAP
                    In-vitro Model PC-3 CVCL_0035 Prostate carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Selenium and genistein act via different molecular mechanisms and exhibit enhanced anticancer effects.
Target and Pathway
Target(s) Thioredoxin reductase 1 (TXNRD1)  Molecule Info  [3]
Thioredoxin reductase 2 (TXNRD2)  Molecule Info  [3]
Thioredoxin reductase 3 (TXNRD3)  Molecule Info  [3]
References
Reference 1 ClinicalTrials.gov (NCT01442727) Selenium in the Treatment of Arsenic Toxicity and Cancers
Reference 2 Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutr Cancer. 2009;61(3):397-407.
Reference 3 An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. J Biol Chem. 2004 Sep 10;279(37):38721-9.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
 Download Picture         KEGG Link