Drug Details

General Information of the Drug (ID: DR9535)
Name
Coralyne
Synonyms
Coralyne chloride; Coralyne; 38989-38-7; (-)-Coralyne chloride hydrate; 6872-73-7; NSC96349; 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium chloride; 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride; EINECS 254-239-2; NSC 96349; NSC 154891; Dibenzo[a, 2,3,10,11-tetramethoxy-8-methyl-, chloride; 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinoline, chloride; 8-Methyl-2,3,10,11-tetramethoxydibenzo(a,g)quinolizinium chloride; 5,6,7,8,13,13a-Hexadehydro-8-methyl-2,3,10,11-tetramethoxyberbinium chloride; DIBENZO(a,g)QUINOLIZINIUM, 8-METHYL-2,3,10,11-TETRAMETHOXY-, CHLORIDE; SPECTRUM1500861; CHEMBL363506; SCHEMBL3320097; DTXSID50959832; HMS1921K20; 2,3,10,11-Tetramethoxy-8-methyldibenzo(a,g)quinolizinium chloride; 5,6,7,8,13,13a-Hexahydro-8-methyl-2,3,10,11-tetramethoxyberbinium; CCG-38524; NSC-96349; NSC154891; SBB056946; AKOS024348916; MCULE-4271694490; NSC-154891; BERBINIUM, 5,6,7,8,13,13a-HEXADEHYDRO-2,3,10,11-TETRAMETHOXY-8-METHYL-, CHLORIDE; NCGC00094866-01; NCGC00094866-02; ST50826325; SR-05000002641; SR-05000002641-1; 2,3,10,11-Tetramethoxy-8-methylisoquinolino[3,2-a]isoquinolin-7-ium chloride; Dibenzo(a,g)quinolizinium, 2,3,10,11-tetramethoxy-8-methyl-, chloride (9CI)
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Molecular Type
Small molecule
Disease Acute lymphoblastic leukemia [ICD-11: 2B33] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C22H22ClNO4
PubChem CID
23306
Canonical SMILES
CC1=C2C=C(C(=CC2=CC3=[N+]1C=CC4=CC(=C(C=C43)OC)OC)OC)OC.[Cl-]
InChI
1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1
InChIKey
PDYBUYVOPAJLKP-UHFFFAOYSA-M
CAS Number
CAS 38989-38-7
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Paclitaxel      Taxus brevifolia     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression BAX  Molecule Info 
Pathway MAP
Down-regulation Expression BCL-2  Molecule Info 
Pathway MAP
                    In-vitro Model MCF-7 CVCL_0031 Invasive breast carcinoma Homo sapiens
MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Paclitaxel in combination with coralyne show a promising therapeutic potential effect in treating breast cancer at lower effective dose.
Target and Pathway
Target(s) PKR-associated protein X (PRKRA)  Molecule Info  [3]
References
Reference 1 Experimental antileukemic agents. Coralyne, analogs, and related compounds. J Med Chem. 1974 Mar;17(3):347-51.
Reference 2 Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.
Reference 3 Treatment of cancer cachexia in mice by combination of dsRNA-dependent protein kinase inhibitor and medroxyprogesterone acetate. Oncol Rep. 2012 Feb;27(2):579-84.
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