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Natural Product (NP) Details

General Information of the NP (ID: NP1023)
Name
Morin
Synonyms
Aurantica; Calico Yellow; Al-Morin; Toxylon Pomiferum; Morin hydrate; 2',3,4',5,7-Pentahydroxyflavone; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Bois d,Arc; Osage Orange; Osage Orange Extract; Bois d'arc; C.I. Natural Yellow 11; C.I. Natural Yellow 8; Osage Orange Crystals; 3,5,7,2',4'-Pentahydroxyflavone; 3,5,7,2',4'-Pentahydroxyflavonol; 2'-Hydroxypelargidenolon 1522; 2',4',3,5,7-Pentahydroxyflavone; C.I. 75660; Zlut prirodni 11; 2',4',5,7-Tetrahydroxyflavan-3-ol; Bois d'arc [French]
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Species Origin Morus serrata ...     Click to Show/Hide
Morus serrata
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Rosales
Family: Moraceae
Genus: Morus
Species: Morus serrata
Garcinia multiflora
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Malpighiales
Family: Clusiaceae
Genus: Garcinia
Species: Garcinia multiflora
Garcinia morella
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Malpighiales
Family: Clusiaceae
Genus: Garcinia
Species: Garcinia morella
Disease Acute lymphoblastic leukemia [ICD-11: 2B33] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C15H10O7
PubChem CID
5281670
Canonical SMILES
C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
InChI
1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
InChIKey
YXOLAZRVSSWPPT-UHFFFAOYSA-N
CAS Number
CAS 480-16-0
Herb ID
HBIN035746
ETMC ID
4885
SymMap ID
SMIT00073
TCMSP ID
MOL000737
TTD Drug ID
D0NJ4H
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          MST312      Lung cancer     Click to Show/Hide the Molecular Data of This Drug
                 Augmenting Drug Sensitivity     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation
Down-regulation Phosphorylation STAT3  Molecule Info 
Pathway MAP
                    In-vitro Model HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
SW620 CVCL_0547 Colon adenocarcinoma Homo sapiens
MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)
Combination treatment with morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Target and Pathway
Target(s) Bcl-2-like protein 3 (MCL1)  Molecule Info  [3]
Fatty acid synthase (FASN)  Molecule Info  [4]
Oestrogen receptor beta (ESR2)  Molecule Info  [3]
Organic anion transporter 4-like (URAT1)  Molecule Info  [5]
Plasmodium 3-oxoacyl-acyl-carrier reductase (Malaria fabG)  Molecule Info  [4]
Plasmodium enoyl-ACP reductase (Malaria fabI)  Molecule Info  [4]
Plasmodium Fatty acid synthesis protein (Malaria FabZ)  Molecule Info  [4]
BioCyc Fatty acid biosynthesis initiation Click to Show/Hide
2 Fatty acid elongation -- saturated
3 Palmitate biosynthesis
KEGG Pathway PI3K-Akt signaling pathway Click to Show/Hide
2 MicroRNAs in cancer
3 Fatty acid biosynthesis
4 Metabolic pathways
5 Fatty acid metabolism
6 AMPK signaling pathway
7 Insulin signaling pathway
8 Estrogen signaling pathway
9 Prolactin signaling pathway
10 Fatty acid biosynthesis
11 Biotin metabolism
12 Metabolic pathways
13 Fatty acid metabolism
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
Panther Pathway Apoptosis signaling pathway Click to Show/Hide
2 CCKR signaling map ST
Pathwhiz Pathway Fatty Acid Biosynthesis Click to Show/Hide
Pathway Interaction Database E2F transcription factor network Click to Show/Hide
2 Direct p53 effectors
3 IL6-mediated signaling events
4 HIF-1-alpha transcription factor network
5 p73 transcription factor network
6 Validated transcriptional targets of deltaNp63 isoforms
7 Plasma membrane estrogen receptor signaling
8 Validated nuclear estrogen receptor beta network
9 Validated nuclear estrogen receptor alpha network
Reactome ChREBP activates metabolic gene expression Click to Show/Hide
2 Activation of gene expression by SREBF (SREBP)
3 Fatty Acyl-CoA Biosynthesis
4 Nuclear Receptor transcription pathway
WikiPathways Apoptosis Click to Show/Hide
2 miR-targeted genes in muscle cell - TarBase
3 miR-targeted genes in lymphocytes - TarBase
4 miR-targeted genes in leukocytes - TarBase
5 Apoptosis Modulation and Signaling
6 Fatty Acid Biosynthesis
7 Nuclear Receptors Meta-Pathway
8 Liver X Receptor Pathway
9 Activation of Gene Expression by SREBP (SREBF)
10 SREBF and miR33 in cholesterol and lipid homeostasis
11 SREBP signalling
12 Metabolism of water-soluble vitamins and cofactors
13 Integration of energy metabolism
14 Fatty acid, triacylglycerol, and ketone body metabolism
15 AMPK Signaling
16 SIDS Susceptibility Pathways
17 Ovarian Infertility Genes
18 Integrated Pancreatic Cancer Pathway
19 Nuclear Receptors
20 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Reference 1 Morin exhibits leukemic cellular apoptosis through caspase pathway. Nat Prod Res. 2020 Jul 16;1-5.
Reference 2 Combination treatment with flavonoid morin and telomerase inhibitor MST?312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98.
Reference 3 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
Reference 4 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
Reference 5 Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) express... Drug Metab Dispos. 2007 Jun;35(6):981-6.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China